“Understanding the determinants of risk and prognosis of molecular breast cancer subtypes”.
Breast CAncer STratification


The Breast Cancer Association Consortium (BCAC) is a well-established, international consortium of 84 epidemiological and clinical breast cancer studies currently including over 100,000 breast cancer patients and a similar number of controls. BCAC also has the largest centralised resource worldwide of breast tumour tissues from over 14,000 patients with well annotated data on risk factors and clinical outcomes. BCAC was central to the recently completed 7th Framework Programme ‘Collaborative Oncological Gene-environment Study’ (COGS). This project was extremely successful in identifying common genetic variants associated with breast  cancer risk, and in determining interactions between environmental and genetic factors. Particularly relevant to B-CAST, it provided evidence that subtypes of breast cancers not only have different clinical manifestations and responses to treatments, but also have different aetiologies and natural histories. This has led to the recognition that more research is needed to better understand the aetiology of the different subtypes and their subsequent prognosis, which in turn should lead to different approaches for prevention and early detection of specific subtypes. See: http://bcac.ccge.medschl.cam.ac.uk/

The BCAC is at the core of the B-CAST project. B-CAST builds upon the knowledge already generated within BCAC, as well as on established scientific collaborations, infrastructure and resources in BCAC.



BCAC – Breast Cancer Association Consortion: http://bcac.ccge.medschl.cam.ac.uk/
COGS – Collaborative Oncological Gene-environment Study: http://www.cogseu.org/
OncoArray – OncoArray Network: http://epi.grants.cancer.gov/oncoarray/
BRIDGES – Breast Cancer Risk after Diagnostic Gene Sequencing: http://bridges-research.eu/