“Understanding the determinants of risk and prognosis of molecular breast cancer subtypes”.
Breast CAncer STratification

WP6: Validation of risk an prognostication models

Lead: KI – Karolinska Institutet
WP leader: Per Hall

WP6 will perform the validation of the risk and prognostication models. The performance of these models will be assessed in order to determine the model calibration, discriminatory capacity, accuracy and incremental predictive/prognostic value of the model. For the validation of the final risk model we have selected European cohorts with extensive information on breast cancer risk factors. The performance of the extended PREDICT model will be evaluated in the longitudinal clinical cohorts of BCAC; we will also liaise with collaborators outside BCAC for external validations of the model as was done previously.

Objectives

  1. To validate and compare the risk prediction models developed in WP5.
  2. To validate the PREDICT prognostic model updated in WP5.