Lead: DKFZ – German Cancer Research Center
WP leader: Jenny Chang-Claude
WP4 will collect and harmonise data on risk factors for breast cancer from participating studies. This builds upon previous work performed in BCAC. In B-CAST we will expand the data collection to include data from new studies; obtain more detailed information on important factors such as modifiable lifestyle risk factors (overweight/obesity, alcohol consumption, physical activity and cigarette smoking); benign breast disease, and medication use including exogenous hormones (oral contraceptive pill and hormone replacement therapy); and comorbidity (e.g. diabetes); and harmonize data across studies/consortia. We will also obtain information on breast screening histories and mammographic density for a subset of studies. WP4 will also integrate data from multiple sources (genetic, lifestyle, density, clinical, molecular) and generate datasets for data analyses utilising a central data storage in order to make it accessible to B-CAST investigators working on data management and analyses from different institutions.
- To assemble, harmonise and manage data for environmental risk factors from participating studies.
- To develop tools and perform comprehensive measures of mammographic density.
- To collate and perform a quality control of germline genotype data.
- To integrate risk factor, clinical and molecular pathology data into a central BCAC/B-CAST database.